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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK2
All Species:
30.3
Human Site:
S625
Identified Species:
55.56
UniProt:
O75116
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75116
NP_004841.2
1388
160900
S625
K
E
F
I
N
L
Q
S
A
L
E
S
E
R
R
Chimpanzee
Pan troglodytes
P61584
1003
117506
A375
K
L
K
E
E
R
E
A
R
E
K
A
E
N
R
Rhesus Macaque
Macaca mulatta
XP_001096931
1524
173861
S761
K
E
F
I
N
L
Q
S
A
L
E
S
E
R
R
Dog
Lupus familis
XP_540083
1519
175559
S756
K
E
F
M
N
L
Q
S
V
L
E
S
E
R
R
Cat
Felis silvestris
Mouse
Mus musculus
P70336
1388
160567
S625
K
E
F
I
N
L
Q
S
A
L
E
S
E
R
R
Rat
Rattus norvegicus
Q62868
1379
159417
S616
K
E
F
I
N
L
Q
S
A
L
E
S
E
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
L568
E
I
D
M
T
Y
K
L
K
V
I
Q
Q
S
L
Chicken
Gallus gallus
XP_419954
1438
166280
S675
K
D
F
L
N
L
Q
S
A
L
E
S
E
R
R
Frog
Xenopus laevis
NP_001154860
1372
159002
S611
K
D
F
I
N
L
Q
S
A
L
E
S
E
R
R
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
A611
R
E
N
I
S
L
Q
A
A
L
D
T
E
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
L640
Y
E
I
E
R
L
E
L
Q
F
S
E
K
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P92199
1173
135756
K544
Q
L
K
E
D
L
R
K
K
S
G
E
L
A
Q
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
T577
Q
E
V
I
R
M
Q
T
Q
L
E
E
E
Q
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.3
90.4
87.8
N.A.
96.6
95.7
N.A.
82.3
86.8
82
75.2
N.A.
24.1
N.A.
34.2
47.4
Protein Similarity:
100
56.9
90.8
89.5
N.A.
98.3
97.4
N.A.
86.2
91.9
89.9
86.6
N.A.
45.2
N.A.
52.8
64.9
P-Site Identity:
100
20
100
86.6
N.A.
100
100
N.A.
0
86.6
93.3
53.3
N.A.
13.3
N.A.
6.6
46.6
P-Site Similarity:
100
46.6
100
93.3
N.A.
100
100
N.A.
33.3
100
100
93.3
N.A.
26.6
N.A.
33.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
16
54
0
0
8
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
8
0
8
0
0
0
0
0
8
0
0
0
0
% D
% Glu:
8
62
0
24
8
0
16
0
0
8
62
24
77
0
0
% E
% Phe:
0
0
54
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
54
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
62
0
16
0
0
0
8
8
16
0
8
0
8
8
0
% K
% Leu:
0
16
0
8
0
77
0
16
0
70
0
0
8
8
8
% L
% Met:
0
0
0
16
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
54
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
16
0
0
0
0
0
70
0
16
0
0
8
8
8
8
% Q
% Arg:
8
0
0
0
16
8
8
0
8
0
0
0
0
54
77
% R
% Ser:
0
0
0
0
8
0
0
54
0
8
8
54
0
8
8
% S
% Thr:
0
0
0
0
8
0
0
8
0
0
0
8
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _